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Rajendra, S. V.
- Aqueous Extract of Aerial Parts of Centella asiatica Arrests Cell Cycle at G0/G1 on Colorectal Cancer Cell Lines
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PDF Views:73
Authors
Affiliations
1 Dr G R Damodaran College of Science, Institute of Management Technology, 214, Rajpur Road, Dehradun-248009, Uttarakhand, IN
2 Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot, Karnataka, IN
3 Krupanidhi College of Pharmacy, Bangalore - 560035, IN
1 Dr G R Damodaran College of Science, Institute of Management Technology, 214, Rajpur Road, Dehradun-248009, Uttarakhand, IN
2 Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot, Karnataka, IN
3 Krupanidhi College of Pharmacy, Bangalore - 560035, IN
Source
Journal of Pharmaceutical Research, Vol 15, No 2 (2016), Pagination: 45-50Abstract
Purpose: To investigate the cytotoxicity and cell cycle analysis of aqueous extract of aerial parts of Centella asiatica on colorectal (HCT116) cancer cell lines.
Approach: Centella asiatica extract was subjected to preliminary phytochemical screening and in the next stage, brine shrimp lethality assay was carried out.MTT assay was also performed on colorectal cancer cell lines to assess the in vitro cytotoxicity activity of the plant extract.Then, cell cycle arrest was also done as a part of investigation using Flow cytometry.
Findings: Phytochemical screening revealed the presence of various vital phytoconstituents like saponins, glycosides, tannins, triterpenoids, flavonoids and polyphenols . Aqueous extract of the aerial parts of Centella asiatica markedly increases the mortality in brine shrimp lethality assay. Further, the extract exhibited cytotoxicity on human colorectal cancer cell lines and cell cycle arrest at G0/G1 phase.
Originality: This research work throws light into the usage of the plant as an alternative to conventional chemotherapy of cancer. In vitro brine shrimp lethality assay, cytotoxicity and cell cycle analysis were all performed for the first time using aqueous extract of Centella asiatica aerial parts.
Conclusion: It can be concluded that the aqueous extract of aerial parts of Centella asiatica showed antioxidant&anticancer activities and even arrested the cell cycle at G0/G1 phase.
Keywords
Centella asiatica, Brine Shrimp Lethality Assay, MTT Assay, Cell Cycle, HCT116, Flow Cytometry.Full Text
References
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- Gupta Y.K., Verendra Kumar M.H., Srivastava A.K. Effect of Centella asiatica on pentylene tetrazole-induced kindling, cognition and oxidative stress in rats. Pharmacology Biochemistry and Behaviour 2003;3:579-585.
- Babu TD and Paddikkala J, Cytotoxic and antitumor properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban, J Ethnopharmacol, 1995, 48(1), 53-57.
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- Semecarpus Anacardium - A Wonderful Plant with Varied Medicinal Properties
Abstract Views :282 |
PDF Views:95
Authors
Affiliations
1 Krupanidhi College of Pharmacy, Chikka Bellandur, Carmelaram Post, Varthur Hobli, Bangalore-560035, IN
1 Krupanidhi College of Pharmacy, Chikka Bellandur, Carmelaram Post, Varthur Hobli, Bangalore-560035, IN
Source
Journal of Pharmaceutical Research, Vol 15, No 4 (2016), Pagination: 162-173Abstract
Purpose: Traditional herbal plants have been used ever since human civilization started for treating various notable disorders. Semecarpus anacardium (SA) commonly called as Bhilwa is an ancient plant known as half physician for its ability to cure almost half of the known disorders and is available in form of various formulations in Ayurveda and siddha system of medicine. In the current review, complete pharmacological utility of the plant along with its geographical location, chemical constituents, its role in apoptosis and various other uses will be discussed.
Approach: Information from the published research article available from Pubmed, google scholar and othersources were used in the preparation of this review article.
Finding: SA has been reported to be a potential plant for the cure of diseases such as diabetes, myocardial infraction, asthma, rheumatoid arthritis, piles, cancer of liver, oesophagus, breast, mouth etc. It is a rich source of antioxidant having high free radical scavenging effect and is useful in treating heart diseases, CNS disorders and in cancer such as hepatocellular carcinoma, mammary carcinoma etc.
Conclusion: SA can be used as an alternative therapy for various ailments however the precise mechanism underlying its various effects has not been determined fully. The phyto constituents present in this plant need to be isolated and can be developed into phyto-pharmaceuticals.
Keywords
Semecarpus Anacardium, Anticancer, Apoptosis, Indigenous System of Medicine.Full Text
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- An overview of Phytoconstituents and Pharmacological Activities of Celastrus paniculatus Willd
Abstract Views :383 |
PDF Views:65
Authors
Affiliations
1 Department of Pharmacology,12/1, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur (H), Bangalore-560035, IN
1 Department of Pharmacology,12/1, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur (H), Bangalore-560035, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 4 (2017), Pagination: 307-313Abstract
Purpose: Herbal drugs are traditionally used in various parts of the world to cure a number of ailments. Celastrus paniculatus Willd is one such herbal plant which has been employed extensively in the treatment of several health conditions in traditional system of medicine. The current review is an effort to summarize the information based on evidence regarding the botanical aspects, phytoconstituents, traditional uses and pharmacological actions of Celastrus paniculatus.
Findings: The leaves have healing effect on injuries while the seeds show significant action on the Central nervous system. The studies on laboratory animals demonstrated various pharmacological actions showing excellent activities on the brain.
Conclusion: Celastrus paniculatus is a versatile plant, as all its plant parts possess the potential to treat several diseases due to the presence of various phytoconstituents. However these constituents have to be further isolated and characterized to check its activity on other common pharmacological disorders.
Keywords
Celastrus Paniculatus, Malkangani, Traditional Medicine, Sesquiterpene Polyalcohol, Phytopharmacology.Full Text
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